This report was commissioned by the GO Virginia Region 3 Council to provide an actionable roadmap for growing the Southern Virginia economy through entrepreneurship and innovation. Mid-Atlantic Broadband Communities Corporation (MBC) and the Longwood University Office of Economic and Community Development were selected to co-lead the development of the strategy, using an approach that focused on entrepreneurship ecosystem building through community engagement with entrepreneurs and ecosystem partners, mapping the ecosystem to determine gaps and opportunities to scale resources, and mapping existing businesses to determine supply chain opportunities, and research into best practices and programs that would be feasible in Region 3. During the timeline of this project, the coronavirus pandemic hit the UnitedStates; therefore, the impact of COVID-19 is referenced throughout the report.